Androgens in SARS-CoV-2 Coronavirus Infections

    December 2021 in “ Physiological Research ”
    L Stárka, Michaela Duskova
    Studysummary This paper reviews the role of androgens in SARS-CoV-2 infection and their potential impact on disease severity, suggesting androgen-targeting strategies might influence outcomes, but reports no new clinical results.
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    Research cited in this study 8

    1. The Double-Edged Sword of Testosterone’s Role in the COVID-19 Pandemic Frontiers in Endocrinology · 2021
    2. Anti-Androgens May Protect Against Severe COVID-19 Outcomes: Results From a Prospective Cohort Study of 77 Hospitalized Men Journal of The European Academy of Dermatology and Venereology · 2021
    3. Clinical Symptoms of Hyperandrogenic Women Diagnosed with COVID-19 Journal of the European Academy of Dermatology and Venereology · 2020
    4. Androgenetic Alopecia Present in the Majority of Patients Hospitalized with COVID-19: The 'Gabrin Sign' Journal of The American Academy of Dermatology · 2020
    5. Androgen Sensitivity Gateway to COVID-19 Disease Severity Drug Development Research · 2020
    6. Racial Variations in COVID-19 Deaths May Be Due to Androgen Receptor Genetic Variants Associated with Prostate Cancer and Androgenetic Alopecia. Are Anti-Androgens a Potential Treatment for COVID-19? Journal of Cosmetic Dermatology · 2020
    7. A Preliminary Observation: Male Pattern Hair Loss Among Hospitalized COVID-19 Patients in Spain – A Potential Clue to the Role of Androgens in COVID-19 Severity Journal of Cosmetic Dermatology · 2020
    8. What Does Androgenetic Alopecia Have to Do with COVID-19? An Insight into a Potential New Therapy Dermatologic Therapy · 2020