Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients

The document discusses the potential use of antiandrogens as therapeutic agents in COVID-19 patients, highlighting the association between androgens and the severity of COVID-19, particularly in men. It notes that androgens regulate the host protease TMPRSS2 and the cell entry protein ACE2, which are crucial for the virus's entry into cells. The review suggests that modulating androgen signaling could be a promising strategy to prevent viral infection, with antiandrogens potentially serving as preventative measures at the pre- or early hospitalisation stages of COVID-19. Various antiandrogens, including those used for prostate cancer, have been tested with varying success as antivirals.