Synthesis and Biological Evaluation of Dimeric Peptide Derivatives as Proliferation-Stimulating Agents in Human Follicle Dermal Papilla Cells

September 2021 in “ Bulletin of the Korean Chemical Society ”

Jisu Jeong, Kyeong‐Yong Park, Jiyeon Kim

dimeric peptide derivatives human follicle dermal papilla cells HFDPCs tripeptide Arg-His-Lys AHK peptide No. 20 Arg-Trp-Lys AWK phosphorylation of ERK1/2 ERK1/2 signaling mRNA expression hair regeneration-related genes VEGF FGF-2 FGF-7 hair regeneration alopecia treatment dimeric peptides ERK1/2

Studysummary In this study, dimeric peptide derivatives were shown to enhance the proliferation of human follicle dermal papilla cells in vitro, particularly promoting the ERK1/2 pathway, suggesting potential for developing peptide-based treatments for hair regeneration.

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