Chapter 20: Advances in Dermatological Treatments

January 1987 in “ Annual reports in medicinal chemistry ”

Michael C. Venuti

alopecia alopecia areata benzoyl peroxide antibiotics psoriasis acute skin inflammation steroids contact allergens dermal metabolism

Studysummary This review discusses recent developments in dermatological treatments for skin conditions such as acne, psoriasis, acute inflammation, and alopecia but reports no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The chapter reviewed advances in dermatological treatments for skin diseases, with a focus on acne, psoriasis, acute skin inflammation, and alopecia. It explained that acne is generally managed with topical benzoyl peroxide or antibiotics, while psoriasis treatment remains palliative, offering only temporary relief. Acute skin inflammation is commonly treated with steroids, despite their side effects. Alopecia areata has been treated with contact allergens, but this is not considered a routine approach. The chapter highlighted that drug side effects and a deeper understanding of dermal metabolism have led to more effective and patient-friendly treatments, although many skin diseases still lack definitive therapies.

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13 / 13 results

research Dose-Response Study of Topical Minoxidil in Male Pattern Baldness

58 citations , July 1986 in “Journal of The American Academy of Dermatology”

Lowest effective minoxidil concentration is 1%, but 2% works better for male pattern baldness.

research Topical Minoxidil Dose-Response Effect in Alopecia Areata

54 citations , February 1986 in “Archives of Dermatology”

This study found that 5% topical minoxidil solution led to greater hair regrowth in severe alopecia areata patients compared to 1% minoxidil, although most regrowth was not cosmetically acceptable.

research Topical Minoxidil in Early Male Pattern Baldness

138 citations , August 1985 in “Journal of The American Academy of Dermatology”

Minoxidil promotes hair growth in male pattern baldness.

research Topical Minoxidil Therapy and Hair Regrowth

20 citations , February 1985 in “Archives of Dermatology”

This report discusses the potential of minoxidil for treating hair loss, spurred by early findings of hair regrowth in some patients, but emphasizes the need for further research to establish its safety and efficacy.

research Topical Minoxidil Therapy in Hereditary Androgenetic Alopecia

55 citations , February 1985 in “Archives of Dermatology”

This study found that 32% of patients with hereditary male pattern baldness experienced cosmetically acceptable hair growth after applying topical minoxidil twice daily, with no serious side effects reported.

research Percutaneous Absorption of Minoxidil in Humans

52 citations , February 1985 in “Archives of Dermatology”

Minoxidil absorbs poorly through skin, with low risk of side effects at 1-2% concentration.

research Topical Minoxidil for Hair Regrowth

80 citations , September 1984 in “Journal of The American Academy of Dermatology”

In this study, 5% topical minoxidil was observed to promote hair regrowth in some patients with androgenic alopecia, while no regrowth was noted in patients with alopecia areata.

Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

137 citations , May 1984 in “Journal of Investigative Dermatology”

Minoxidil increases blood flow in balding scalps, possibly reversing hair loss.

research Direct Effects of Minoxidil on Epidermal Cells in Culture

63 citations , January 1984 in “Journal of Investigative Dermatology”

Minoxidil promotes hair growth by increasing cell division and DNA synthesis.

research Effect of Minoxidil on Cultured Keratinocytes

72 citations , December 1983 in “Journal of Investigative Dermatology”

Minoxidil helps hair cells live longer and grow longer.

research Topical Minoxidil in the Treatment of Alopecia Areata

80 citations , October 1983 in “BMJ”

This study found that 1% topical minoxidil induced significant hair regrowth in patients with alopecia areata, though it was less effective for those with extensive hair loss such as alopecia totalis and universalis.

research Antipsoriatic Activity of a New Synthetic Retinoid

20 citations , September 1983 in “Archives of dermatology”

This study observed that minimal doses of the arotinoid RO 13-6298 successfully treated two cases of severe psoriasis and psoriatic arthritis unresponsive to traditional therapies, despite some side effects.

research Recent Advances in the Treatment of Psoriasis

29 citations , March 1983 in “Journal of The American Academy of Dermatology”

This article reviews existing and emerging treatments for psoriasis, focusing on therapy modifications due to scientific advancements, but it does not report new clinical results.