A Case of Lupus Miliaris Disseminatus Faciei After Allogeneic Hematopoietic Stem Cell Transplantation

    August 2019 in “ Chinese Medical Journal ”
    Si Zhang, Xiaoyang Liu, Lin Cai, Chen Zhou, Jianzhong Zhang
    TLDR A man developed facial skin lesions after a stem cell transplant, which improved with specific treatments.
    A 43-year-old man developed lupus miliaris disseminatus faciei (LMDF) after discontinuing cyclosporine A following an allogeneic hematopoietic stem cell transplantation. The patient presented with multiple reddish-brown papules on his face, which were confirmed through histopathological analysis to be epithelioid cell granulomas with caseation necrosis. Despite negative tuberculosis tests, the condition was treated effectively with a 6-month regimen of oral isotretinoin and topical tacrolimus, resulting in significant improvement. The case suggested that immunological changes post-transplantation might contribute to LMDF pathogenesis.
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