Long-Lived Proteins and DNA as Candidate Predictive Biomarkers for Tissue-Associated Diseases

This study explores long-lived proteins (LLPs) and DNA renewal in mice, identifying 2,113 LLPs across 10 tissues and plasma, which may serve as biomarkers for aging and age-related diseases. Tissue-specific LLPs were found, with brain LLPs linked to neurodegenerative diseases and plasma LLPs potentially related to cardiovascular diseases. The research suggests that LLPs, due to their low turnover and increased vulnerability, could provide insights into tissue susceptibility to diseases. The study also highlights the association of LLPs with diseases such as myocardial infarction, kidney failure, and androgenetic alopecia, which is linked to coronary artery disease. LLPs' stability and involvement in critical pathways could offer valuable insights into disease mechanisms, although limitations exist in detecting low-abundance LLPs and the influence of tissue growth on LLP categorization.