Lichen Planopilaris: A Therapeutic Management Review

    May 2015 in “ Journal of The American Academy of Dermatology ”
    Image of study
    TLDR Mycophenolate mofetil may improve symptoms and stop hair loss in Lichen planopilaris, but more research is needed.
    The document reviews the therapeutic management of Lichen planopilaris (LPP), a chronic lymphocytic cicatricial alopecia with an unknown pathophysiology, through a case study of a 40-year-old female with a 20-year history of the condition. Initial treatments with oral methylprednisolone and intralesional triamcinolone were unsuccessful, as was a three-month trial of methotrexate and clobetasol scalp solution. However, after two months of treatment with mycophenolate mofetil, the patient reported symptomatic improvement and cessation of further hair loss. The review emphasizes the challenge of treating LPP due to its unclear pathophysiology and the lack of prospective double-blinded studies, highlighting the need for randomized and controlled prospective studies to advance the understanding and treatment of LPP. No commercial support was identified for this study.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 37 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 2 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community Anger and frustration as I finally learn my diagnosis.

      in Female  6 upvotes 1 year ago
      A young female diagnosed with Lichen planopilaris (LPP) experienced years of misdiagnosis and ineffective treatments, including a hair transplant and other procedures. She is considering litigation due to the misdiagnosis and has learned that LPP is chronic, hair loss can be stopped with ongoing medication, but lost hair cannot regrow.

      community C’est terrible - at my wits end

      in Female  443 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  81 upvotes 1 year ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

    Similar Research

    5 / 1000+ results