Lentivirus-Mediated Subcutaneous JAM-A Modification Promotes Skin Wound Healing in a Mouse Model by Strengthening the Secretory Function and Proliferation of Fibroblasts

    April 2022 in “ Cell Biology International ”
    Teng Gong, Minjuan Wu, Xiaoming Fan, Zhaohong Chen, Zhaofan Xia
    TLDR JAM-A modification speeds up skin wound healing by boosting fibroblast growth.
    The study investigated the effect of junctional adhesion molecule A (JAM-A) modification on wound healing in a mouse model. Researchers found that JAM-A modification at the skin wound edge accelerated the healing process, as evidenced by smaller wound sizes and improved skin morphology, including thicker epidermal layers and more hair follicle-like structures by Day 21. The JAM-A-modified fibroblasts showed increased proliferation, and there were elevated levels of growth factors bFGF and EGF, suggesting these factors played a role in the enhanced healing. This indicated that JAM-A modification significantly promoted fibroblast proliferation and wound healing.
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