Lentivirus-Mediated Subcutaneous JAM-A Modification Promotes Skin Wound Healing in a Mouse Model by Strengthening the Secretory Function and Proliferation of Fibroblasts

    April 2022 in “ Cell Biology International ”
    Teng Gong, Minjuan Wu, Xiaoming Fan, Zhaohong Chen, Zhaofan Xia
    TLDR JAM-A modification speeds up skin wound healing by boosting fibroblast growth.
    The study investigated the effects of junctional adhesion molecule A (JAM-A) modification on wound healing in a mouse model. Researchers found that JAM-A modification at the wound edge significantly accelerated the healing process. Mice with JAM-A-overexpressing wounds showed smaller wound sizes by Day 7 and developed thicker epidermal layers and more hair follicle-like structures by Day 21 compared to controls. The modification enhanced fibroblast proliferation and increased the expression of growth factors bFGF and EGF, both in vivo and in vitro. These findings suggested that JAM-A modification could be a promising therapeutic target for improving wound healing.
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