Latent Polyglandular Autoimmune Syndrome Type 2 Case Diagnosed During a Shock Manifestation

January 2016 in “ Gynecological Endocrinology ”

Eren Gürkan, Berrin Çetinarslan, İsmail Güzelmansur, Beyza Kocabaş

polyglandular autoimmune syndrome type 2 PAS-2 Addison's disease autoimmune thyroid disease type 1 diabetes mellitus alopecia vitiligo type 1 diabetes hair loss skin depigmentation

TLDR A hidden autoimmune syndrome was found during a shock, showing thyroid, adrenal, and ovarian issues.

A case of latent polyglandular autoimmune syndrome type 2 (PAS-2) was diagnosed during an adrenal crisis. The patient exhibited thyroid, adrenal, and ovarian involvement at the time of diagnosis. PAS-2 typically requires the presence of Addison's disease along with autoimmune thyroid disease and/or type 1 diabetes mellitus, and may include comorbidities such as alopecia, vitiligo, and others. The case highlighted that latent PAS is more common than its manifest forms, prompting a discussion on PAS-2 and potential immunologic disorders.

View this study on doi.org →

Discuss this study in the Community →

Similar Research

5 / 115 results

research Type 1 Diabetes Mellitus and Autoimmune Diseases: A Critical Review of the Association and the Application of Personalized Medicine

12 citations, February 2023 in “Journal of Personalized Medicine”

Type 1 diabetes often occurs with other autoimmune diseases, and personalized treatment based on genetics can improve outcomes.

research Thyroid Diseases and Skin Autoimmunity

24 citations, June 2018 in “Reviews in endocrine and metabolic disorders”

Thyroid diseases may contribute to autoimmune skin diseases, and more research is needed on their relationship.

research Cutaneous Manifestations in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy: A Comprehensive Review

January 2024 in “Biomedicines”

The review shows that skin symptoms like chronic fungal infections, hair loss, and skin depigmentation are key for early detection and management of APECED.

research Skin Manifestations of Endocrine Diseases

4 citations, January 2015 in “Türk Patoloji Dergisi”

Hormone imbalances from endocrine diseases can cause various skin conditions that help diagnose and treat these diseases early.

research Endocrinology

April 2023 in “Clinical Chemistry and Laboratory Medicine”

The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.