Latent Polyglandular Autoimmune Syndrome Type 2 Case Diagnosed During a Shock Manifestation

January 2016 in “ Gynecological Endocrinology ”

Eren Gürkan, Berrin Çetinarslan, İsmail Güzelmansur, Beyza Kocabaş

polyglandular autoimmune syndrome type 2 PAS-2 Addison's disease autoimmune thyroid disease type 1 diabetes mellitus alopecia vitiligo type 1 diabetes hair loss skin depigmentation

TLDR A hidden autoimmune syndrome was found during a shock, showing thyroid, adrenal, and ovarian issues.

A case of latent polyglandular autoimmune syndrome type 2 (PAS-2) was diagnosed during an adrenal crisis. The patient exhibited thyroid, adrenal, and ovarian involvement at the time of diagnosis. PAS-2 typically requires the presence of Addison's disease along with autoimmune thyroid disease and/or type 1 diabetes mellitus, and may include comorbidities such as alopecia, vitiligo, and others. The case highlighted that latent PAS is more common than its manifest forms, prompting a discussion on PAS-2 and potential immunologic disorders.

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