Lam/Tsc Cell Migration to Uterus in an Experimental Model of Lymphangioleiomyomatosis: Regulation by Anti-Epidermal Growth Factor Receptor Antibody and Rapamycin

January 2014 in “ Journal of Cytology & Histology ”

Eloisa Chiaramonte Silvia Ancona

rapamycin anti-EGFR antibody angiogenesis LAM/TSC cells epidermal growth factor receptor EGFR

TLDR Rapamycin and anti-EGFR antibody reduce LAM/TSC cell migration and blood vessel growth in the uterus.

The study investigated the migration and invasion of human LAM/TSC cells to the uterus using a mouse model, revealing that these cells could migrate without causing morphological lesions but increased angiogenesis. The research involved administering LAM/TSC cells to immunodeficient female nude mice and treating them with rapamycin and anti-EGFR antibody. Both treatments effectively reduced the number of LAM/TSC cells and the proliferation of blood vessels in the uterus, although they did not alter lymphatic vessel expression. This highlighted the strong invasive capability of LAM/TSC cells and the potential of these treatments in managing LAM-related angiogenesis.

View this study on doi.org →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research Lam/Tsc Cell Migration to Uterus in an Experimental Model of Lymphangioleiomyomatosis: Regulation by Anti-Epidermal Growth Factor Receptor Antibody and Rapamycin

2 citations , January 2014 in “Journal of Cytology & Histology”

Rapamycin and anti-EGFR antibody reduce LAM/TSC cell migration and blood vessel growth in the uterus.

research Human TSC2-Null Fibroblast-Like Cells Induce Hair Follicle Neogenesis and Hamartoma Morphogenesis

36 citations , March 2011 in “Nature Communications”

Cells from a skin condition can create new hair follicles and similar growths in mice, and a specific treatment can reduce these effects.

Related Community Posts Join

6 / 23 results

community Topical rapamycin, metformin, a-kg grow hair

in Research/Science 13 upvotes 5 years ago

The conversation discusses the potential of topical rapamycin, metformin, and alpha-ketoglutarate (a-KG) for hair growth, with skepticism expressed about their effectiveness based on personal experience and existing use. It also mentions AICAR, known as cardarine or GW, which is not suitable for long-term use due to cancer risks in animal studies and its similarity to metformin.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 742 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Chat is this real? Compound called clascoterone

in Research/Science 557 upvotes 4 days ago

Clascoterone shows promising results for hair regrowth in men with androgenetic alopecia, with potential FDA approval by 2026. It acts as a topical androgen receptor blocker, offering a new treatment option with minimal side effects compared to existing treatments like finasteride.

community Is there any new drug that looks promising ?

in Research/Science 25 upvotes 1 year ago

The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 123 upvotes 1 year ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

Similar Research

5 / 613 results