Combination of Baricitinib and Conventional Immunomodulating Therapy for Alopecia Totalis

July 2023 in “ Skin Research and Technology ”

Young Gue Koh, Hye Sung Han, Joon Seok, Sun Young Choi, Kapsok Li, Beom Joon Kim, Kwang Ho Yoo

From the encyclopedia

JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Tofacitinib →

a JAK inhibitor for alopecia areata and other autoimmune conditions

Studysummary This study reports that combining baricitinib with low-dose cyclosporine and steroids resulted in effective and safe treatment for a case of alopecia totalis, maintaining hair regrowth without adverse effects.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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research Trichoscopy Patterns in Alopecia Areata: A Systematic Review and Meta-Analysis

2 citations , June 2023 in “Skin Research and Technology”

This study reviewed 39 studies with 3204 patients to identify characteristic trichoscopic findings in alopecia areata, highlighting yellow and black dots, broken, short vellus, and tapering hairs as key indicators. It found no single diagnostic trichoscopic finding but observed trichoscopy's utility in monitoring treatment response.

research Two Phase 3 Trials of Baricitinib for Alopecia Areata

148 citations , March 2022 in “The New England Journal of Medicine”

In two phase 3 trials, this study found that oral baricitinib significantly improved hair regrowth compared to placebo in adults with severe alopecia areata after 36 weeks, though longer trials are needed to ascertain its long-term efficacy and safety.