467 citations
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May 1999 in “Molecular Cell” In this study, activation of c-MycER in adult mouse epidermis rapidly induced proliferation and disrupted keratinocyte differentiation, causing changes similar to precancerous lesions, which regressed once c-MycER was deactivated.
42 citations
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December 2016 in “Cell Death & Differentiation” This study found that transient mtDNA double strand breaks in mice accelerated aging in certain tissues through increased reactive oxygen species, independent of p21/p53 pathway mediation.
30 citations
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April 2010 in “Cell Cycle” This review discusses how the p53 tumor suppressor gene helps maintain adult tissue homeostasis by promoting the removal of DNA-damaged cells, with implications for treating age-related diseases and p53-deficient cancers; it reports no new results.
This study found that simultaneous inactivation of pRb and p53 genes in mice's epidermis accelerates aggressive squamous cell carcinoma development, highlighting p53 as a key tumor suppressor.
2 citations
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December 2020 in “Developmental cell” In this study, DNA cross-linking agents used in cancer therapy were found to cause unintended hyperplasia and fate mis-specification in normal epithelial stem cells through inflammasome activation in dermal fibroblasts.