February 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study reports that spironolactone has shown effectiveness in improving hair density and reducing shedding in female pattern hair loss, particularly for women with hyperandrogenism, though benefits often diminish after stopping treatment.
January 2005 in “NEJM Journal Watch” This article discusses treatments for female-pattern hair loss, such as topical minoxidil and antiandrogens like spironolactone, and reports no new clinical results.
February 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study reports that spironolactone, a potassium-sparing diuretic with antiandrogenic activity, effectively improves hair density, reduces shedding, and stabilizes symptoms in female pattern hair loss, though symptoms often recur after discontinuation, suggesting the need for sustained therapy.
7 citations
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January 1990 This study found that spironolactone at doses of 75 or 100 mg per day did not improve hair density after six months in women with female pattern hair loss, suggesting that higher doses may be necessary.
September 2025 in “International Journal of Women’s Dermatology” This study found that oral spironolactone 100 mg daily for 24 weeks improved terminal hair counts and diameters in premenopausal women with female pattern hair loss when used alongside minoxidil, despite a higher incidence of menstrual irregularities.
26 citations
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September 2015 in “Journal of The American Academy of Dermatology” In this study, spironolactone was reported to stabilize or improve female pattern hair loss in 74.3% of treated women, especially those with signs of hyperandrogenism.
