Quantitative Assessment of Spironolactone Treatment in Women with Diffuse Androgen-Dependent Alopecia

    January 1990
    D. H. Rushton, Walter Futterweit, D. H. Kingsley, Philip J. Kingsley, Michael Norris
    TLDR Spironolactone improved hair density and quality in women with hair loss.
    In a study from 1990, researchers investigated the effects of spironolactone on women with diffuse androgen-dependent alopecia. The study involved 12 women who were treated for 6 months with either 75 or 100 mg of spironolactone per day, while 6 women remained untreated as a control group. The results showed that the treated group experienced a significant increase in total hair density and anagen hair percentage, as well as a decrease in telogen hair percentage, compared to the control group. The study suggested that doses higher than 150 mg per day might be necessary to further improve hair quality and increase hair density. However, the researchers noted that additional long-term studies were needed to confirm these findings.
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