Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

    November 2008 in “ Journal of biological chemistry/˜The œJournal of biological chemistry ”
    Michelle Shih, Maureen A. Kane, Ping Zhou … Robert V. Farese
    Studysummary This study found that DGAT1 functions as a key enzyme in murine skin to regulate retinoic acid levels and prevent retinoid toxicity, impacting hair cycle and sensitivity to retinol.
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    Research cited in this study 9

    1. Pharmacologic Modulation of Sebaceous Gland Activity: Mechanisms and Clinical Applications Dermatologic Clinics · 2007
    2. Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    3. The Triacylglycerol Synthesis Enzyme DGAT1 Also Catalyzes the Synthesis of Diacylglycerols, Waxes, and Retinyl Esters Journal of lipid research · 2005
    4. Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005
    5. Hair Cycle-Specific Immunolocalization of Retinoic Acid Synthesizing Enzymes Aldh1a2 and Aldh1a3 Indicate Complex Regulation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    6. Expression of Desmoglein 1 Compensates for Genetic Loss of Desmoglein 3 in Keratinocyte Adhesion Journal of Investigative Dermatology · 2002
    7. Novel Cycle Changes in Scalp Hair Are Caused by Etretinate Therapy British Journal of Dermatology · 1995
    8. Effect of Retinoids on Follicular Cells ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    9. Topical Tretinoin for Hair Growth Promotion Journal of the American Academy of Dermatology · 1986