TLDR L-borneol helps skin wound healing by promoting stem cell differentiation.
The study establishes a stable system for isolating and culturing rat whisker hair follicle stem cells (HFSCs) and demonstrates that L-borneol, a component of Chinese medicine derived from Cinnamomum camphora, promotes the differentiation of HFSCs into basal cells, aiding in skin wound repair. The research identifies rno-miR-127 as a novel microRNA that regulates this differentiation by targeting and negatively regulating PODXL2. The findings suggest that L-borneol facilitates skin injury repair by promoting HFSC differentiation through the negative regulation of PODXL2 by rno-miR-127, as demonstrated in a rat full-thickness skin defect model.
2 citations
,
June 2022 in “Scientific reports” Mouse hair follicle stem cells lose their ability to change into different cell types after being grown for a long time.
5 citations
,
April 2022 in “Frontiers in Medicine” Hair and skin healing involve complex cell interactions controlled by specific molecules and pathways, and hair follicle cells can help repair skin wounds.
8 citations
,
January 2022 in “Burns and trauma” Skin cell-derived vesicles can help heal skin injuries effectively.
169 citations
,
January 2020 in “Burns & Trauma” Platelet-rich plasma speeds up skin wound healing.
19 citations
,
May 2018 in “Molecular Medicine Reports” miR‑339‑5p can slow down hair follicle stem cell differentiation by targeting DLX5.
27 citations
,
January 2006 in “Colloids and Surfaces B: Biointerfaces” Researchers found that bulge cells from human hair can grow quickly in culture and have properties of hair follicle stem cells, which could be useful for skin treatments.
Exosome therapy could help hair growth but needs more research for safety and effectiveness.
15 citations
,
October 2021 in “Frontiers in Pharmacology” Natural volatiles and essential oils have health benefits and can enhance the effects of some medicines, but more research is needed to understand how they work and their possible side effects.
4 citations
,
August 2017 in “Cosmetics” The extract reduced sebum production and promoted hair growth.
Nanocarriers with plant extracts show promise for safe and effective hair growth treatment.
41 citations
,
July 2015 in “Current Drug Discovery Technologies” Some plants may help with hair growth and have fewer side effects than synthetic drugs, but more research is needed to confirm their effectiveness.
