L-Borneol Regulates rno-miR-127/PODXL2 to Promote Hair Follicle Stem Cells to Repair Skin Wounds

May 2025 in “ International Immunopharmacology ”

Zhiruo Liu, Bangming Ye, Haoxiang Ye, Qing Zhong, Jian Kong, Xianxi Zhou, Chunmei Ma, Aijun Liu

L-borneol hair follicle stem cells HFSCs rno-miR-127 PODXL2 basal cells skin wound repair microRNA Cinnamomum camphora camphor

TLDR L-borneol helps skin wound healing by promoting stem cell differentiation.

The study establishes a stable system for isolating and culturing rat whisker hair follicle stem cells (HFSCs) and demonstrates that L-borneol, a component of Chinese medicine derived from Cinnamomum camphora, promotes the differentiation of HFSCs into basal cells, aiding in skin wound repair. The research identifies rno-miR-127 as a novel microRNA that regulates this differentiation by targeting and negatively regulating PODXL2. The findings suggest that L-borneol facilitates skin injury repair by promoting HFSC differentiation through the negative regulation of PODXL2 by rno-miR-127, as demonstrated in a rat full-thickness skin defect model.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

research Recent Progress in Hair Follicle Stem Cell Markers and Their Regulatory Roles

13 citations , February 2024 in “World Journal of Stem Cells”

New markers help understand and use hair follicle stem cells for regeneration.

research Impaired Differentiation Potential of CD34-Positive Cells Derived from Mouse Hair Follicles After Long-Term Culture

2 citations , June 2022 in “Scientific reports”

Mouse hair follicle stem cells lose their ability to change into different cell types after being grown for a long time.

research Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing

5 citations , April 2022 in “Frontiers in Medicine”

Hair and skin healing involve complex cell interactions controlled by specific molecules and pathways, and hair follicle cells can help repair skin wounds.

research Skin Cell-Derived Extracellular Vesicles: A Promising Therapeutic Strategy for Cutaneous Injury

8 citations , January 2022 in “Burns and trauma”

Skin cell-derived vesicles can help heal skin injuries effectively.

research Platelet-Rich Plasma Accelerates Skin Wound Healing by Promoting Re-Epithelialization

169 citations , January 2020 in “Burns & Trauma”

Platelet-rich plasma speeds up skin wound healing.

research MiR-339-5p Negatively Regulates Loureirin A-Induced Hair Follicle Stem Cell Differentiation by Targeting DLX5

19 citations , May 2018 in “Molecular Medicine Reports”

miR‑339‑5p can slow down hair follicle stem cell differentiation by targeting DLX5.

research Bulge Cells of Human Hair Follicles: Segregation, Cultivation, and Properties

27 citations , January 2006 in “Colloids and Surfaces B: Biointerfaces”

Researchers found that bulge cells from human hair can grow quickly in culture and have properties of hair follicle stem cells, which could be useful for skin treatments.

Similar Research

5 / 1000+ results

research Pharmacology of Natural Volatiles and Essential Oils in Food, Therapy, and Disease Prophylaxis

15 citations , October 2021 in “Frontiers in Pharmacology”

Natural volatiles and essential oils have health benefits and can enhance the effects of some medicines, but more research is needed to understand how they work and their possible side effects.

research A Scoping Review of Exosome Delivery Applications in Hair Loss

March 2025 in “Cureus”

Exosome therapy could help hair growth but needs more research for safety and effectiveness.

Evaluation of the Effect of Plant Mixture Ethanol Extracts Containing Biota Orientalis L. Extract on Suppression of Sebum in Cultured Sebocytes and on Stimulation of Growth of Keratinocytes Co-cultured with Hair Papilla Cells

research Evaluation of the Effect of Plant Mixture Ethanol Extracts Containing Biota Orientalis L. Extract on Suppression of Sebum in Cultured Sebocytes and on Stimulation of Growth of Keratinocytes Co-cultured with Hair Papilla Cells

4 citations , August 2017 in “Cosmetics”

The extract reduced sebum production and promoted hair growth.

research Bioactive Compound-Loaded Nanocarriers for Hair Growth Promotion: Current Status and Future Perspectives

October 2023 in “Plants”

Nanocarriers with plant extracts show promise for safe and effective hair growth treatment.

research Healing Hair Naturally: A Focus on Herbal Treatment for Hair Disorders

January 2025 in “International Journal of Pharmacognosy and Life Science”

Herbal treatments like Aloe vera, Bhringraj, Neem, Tea tree oil, Amla, and Hibiscus are promising for safer, effective hair care.

L-Borneol Regulates rno-miR-127/PODXL2 to Promote Hair Follicle Stem Cells to Repair Skin Wounds

Research cited in this study

research Recent Progress in Hair Follicle Stem Cell Markers and Their Regulatory Roles

research Impaired Differentiation Potential of CD34-Positive Cells Derived from Mouse Hair Follicles After Long-Term Culture

research Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing

research Skin Cell-Derived Extracellular Vesicles: A Promising Therapeutic Strategy for Cutaneous Injury

research Platelet-Rich Plasma Accelerates Skin Wound Healing by Promoting Re-Epithelialization

research MiR-339-5p Negatively Regulates Loureirin A-Induced Hair Follicle Stem Cell Differentiation by Targeting DLX5

research Bulge Cells of Human Hair Follicles: Segregation, Cultivation, and Properties

Related Community Posts Join

community Extreme hair and beard growth from Stemoxydine. Big 3 + 1?

community 3 month progress on Topical Minoxidil/Finasteride (Hims), oils, and derma-rolling

community Almost 11 months on finasteride, continuing with only fin for now. 25M, 1.25mg daily.

community 2 months progress?? on fin 1mg everyday and derma rolling .5 once a week.

community I just bought Hair Gro by New Nordic. Has anyone else used it before?