L-Borneol Regulates rno-miR-127/PODXL2 to Promote Hair Follicle Stem Cells to Repair Skin Wounds

    May 2025 in “ International Immunopharmacology ”
    Zhiruo Liu, Bangming Ye, Haoxiang Ye … Aijun Liu
    Studysummary This study found that L-borneol, derived from Chinese medicine, significantly promotes the differentiation of rat hair follicle stem cells into basal layer cells, aiding wound healing, with the process involving inhibition of the PODXL2 gene by the microRNA rno-miR-127.
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    Research cited in this study 7

    1. Recent Progress in Hair Follicle Stem Cell Markers and Their Regulatory Roles World Journal of Stem Cells · 2024
    2. Impaired Differentiation Potential of CD34-Positive Cells Derived from Mouse Hair Follicles After Long-Term Culture Scientific reports · 2022
    3. Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing Frontiers in Medicine · 2022
    4. Skin Cell-Derived Extracellular Vesicles: A Promising Therapeutic Strategy for Cutaneous Injury Burns and trauma · 2022
    5. Platelet-Rich Plasma Accelerates Skin Wound Healing by Promoting Re-Epithelialization Burns & Trauma · 2020
    6. MiR-339-5p Negatively Regulates Loureirin A-Induced Hair Follicle Stem Cell Differentiation by Targeting DLX5 Molecular Medicine Reports · 2018
    7. Bulge Cells of Human Hair Follicles: Segregation, Cultivation, and Properties Colloids and Surfaces B: Biointerfaces · 2006