KRT6A Derived From Mesenchymal Stem Cells as a Potential Biomarker and Therapeutic Target for Alopecia Areata: Insights From Multi-Omics Analysis and Experimental Evidence

May 2026 in “ Stem Cell Research & Therapy ”

Shixiong Peng, Jia Deng, Xiuming Meng, Deng Shuangjie, Wenjie Yan, Xi Huang

New to Alopecia Areata? There is a guide in the encyclopedia. Read the guide →

KRT6A mesenchymal stem cells alopecia areata multi-omics analysis hair follicle mesenchymal stem cells MSCs AA HFMSCs

Studysummary In this study, researchers identified KRT6A as a potentially important gene in mesenchymal stem cell-derived treatments for alopecia areata, revealing its role as a diagnostic marker, predictor of disease severity, and a protective factor, with overexpression alleviating hair loss in experimental models.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

View this study on link.springer.com →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research Meta-Analysis of Gene Expression Reveals the Core Transcriptomic Profile of Lesional Scalp in Alopecia Areata

August 2025 in “Dermatology and Therapy”

This study conducted a meta-analysis of gene expression data from alopecia areata patients, identifying 5109 differentially expressed genes and highlighting enriched pathways like JAK-STAT signaling, providing insights into the disease's pathogenesis and potential treatment targets.

research Performance exploration of multi-gene panels of alopecia areata susceptibility and drug-binding targets

1 citations , March 2025 in “Frontiers in Physiology”

This study identified key genes linked to immune cells and potential therapeutic compounds for alopecia areata by evaluating upregulated genes from patient datasets, highlighting T and NK cell involvement in hair follicle attack and suggesting drug candidates through molecular docking and dynamics simulations.

research Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82

9 citations , February 2022 in “Nature communications”

This study identified KRT82 as a significant Alopecia Areata risk gene, finding that rare damaging variants are linked to elevated immune cell infiltration around hair follicles in affected individuals.

research A transcriptomic map of murine and human alopecia areata

26 citations , May 2020 in “JCI Insight”

In this study, single-cell sequencing revealed clonal expansions of CD4+ and CD8+ T cells in murine and human alopecia areata, supporting the development of predictive models for human disease.

Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations

research Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations

10 citations , January 2010 in “Acta Histochemica Et Cytochemica”

This study found that patients with alopecia areata and androgenetic alopecia showed increased c-kit expression and decreased Ki-67 expression in hair follicle cells compared to controls, suggesting a possible feedback mechanism involving stem cell factor signaling.