Altered Expression of Keratin 14 in Lesional Epidermis of Autoimmune Skin Diseases

    November 2015 in “ International Journal of Dermatology ”
    Xiaoying Wei, Katharina Fricker, Alexander Enk, Eva Hadaschik
    TLDR Keratin 14 may be an autoantigen in autoimmune skin diseases.
    The study investigated the expression of Keratin 14 (K14) in autoimmune skin diseases (ASD) by analyzing skin samples from 58 patients with various ASDs and 17 healthy individuals. It was found that in patients with ASD, K14 expression was retained in suprabasal layers, with a focal loss observed in the basal layer and hair follicles, particularly in conditions with interface dermatitis. Additionally, a dot-like K14 staining was noted in the papillary dermis, especially in cutaneous lupus erythematosus and lichen ruber. Western blot analysis revealed that sera from ASD patients recognized recombinantly expressed K14, suggesting that K14 might act as an autoantigen in these diseases.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 152 results

      community This serum outperformed Minoxidil in a recent study. Please debunk

       23 upvotes 6 years ago
      A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

      community Losing ground after 14 months of fin use and 11 months of min

      in Finasteride/Dutasteride  52 upvotes 3 years ago
      A 24-year-old person who is worried about their hair loss after 14 months of taking finasteride and 11 months of minoxidil. Replies to the post suggested sticking with their current regimen, that shedding from one part may not be telogen effluvium, and that shedding is normal with these drugs and they should evaluate in two to three months.

      community My personal experience/observations fighting AGA seriously for 5 years

      in Treatment  47 upvotes 10 months ago
      Minoxidil with alcohol and propylene glycol was more effective than non-alcohol versions, and RU58841 worked best in a non-water-based solution. Oral finasteride showed better results than topical, despite side effects; microneedling and tretinoin worsened hair loss, and PRP was only helpful when younger.

      community Summary of Procapil video by Haircafe

      in Minoxidil  2 upvotes 3 months ago
      Procapil is marketed as a natural hair loss treatment but lacks strong evidence and is industry-biased. Minoxidil and Finasteride are the only FDA-approved treatments for androgenetic alopecia.

      community Hairloss has destroyed my Life completely

      in Chat  339 upvotes 4 months ago
      A young person is distressed about rapid hair loss despite using finasteride and recently starting oral minoxidil. Many suggest continuing treatment, considering dutasteride, and seeking therapy for mental health support.
      M32 Saw palmetto, minoxidil, nizoral, dermaroller

      community M32 Saw palmetto, minoxidil, nizoral, dermaroller

      in Journals / Progress Pictures  391 upvotes 5 months ago
      The user replaced finasteride with saw palmetto due to availability issues and experienced side effects, leading to adjustments in their regimen. They use saw palmetto, minoxidil, Nizoral, and a dermaroller, reporting reduced side effects and some benefits, with hair fall ranging from 5 to 20 hairs daily.

    Related Research

    1 / 1 results