Polygenic Control of the Wavy Coat of the NCT Mouse: Involvement of an Intracisternal A Particle Insertional Mutation of the Protease, Serine 53 (Prss53) Gene, and a Modifier Gene

    January 2022 in “ Mammalian Genome ”
    Masayuki Mori, Chang Liu, Takahiro Yoshizawa … Keiichi Higuchi
    Studysummary This study found that the wavy coat trait in Nakano cataract mice is polygenic, involving major and minor genes, and resembles human curly scalp hair associated with the PRSS53 gene alteration.
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    Research cited in this study 8

    1. The Biology And Genetics Of Curly Hair Experimental Dermatology · 2017
    2. A Genome-Wide Association Scan in Admixed Latin Americans Identifies Loci Influencing Facial and Scalp Hair Features Nature Communications · 2016
    3. Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: An Update Journal of Dermatological Science · 2012
    4. The Mouse Frizzy (Fr) And Rat ‘Hairless’ (FrCR) Mutations Are Natural Variants Of Protease Serine S1 Family Member 8 (Prss8) Experimental Dermatology · 2010
    5. Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans American journal of human genetics · 2009
    6. Worldwide Diversity of Hair Curliness: A New Method of Assessment International Journal of Dermatology · 2007
    7. A Small Deletion Hotspot in the Type II Keratin Gene mK6irs1/Krt2-6g on Mouse Chromosome 15, a Candidate for Causing the Wavy Hair of the Caracul (Ca) Mutation Genetics · 2003
    8. Mice With a Null Mutation of the TGFα Gene Have Abnormal Skin Architecture, Wavy Hair, and Curly Whiskers and Often Develop Corneal Inflammation Cell · 1993