Investigation of Topical Application of Procyanidin B-2 from Apple to Identify Its Potential Use as a Hair Growing Agent

    December 2000 in “ Phytomedicine ”
    Ayako Kamimura, Tomoya Takahashi, Yasusi Watanabe
    Studysummary In this study, 1% procyanidin B-2 tonic significantly increased the number of total and terminal hairs on the scalp of male participants compared to a placebo after 6 months of use.
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    Research cited in this study 14

    1. Toxicological Studies on Procyanidin B-2 for External Application as a Hair Growing Agent Food and chemical toxicology · 1999
    2. Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1999
    3. Acquired Scalp Alopecia: A Review Australasian Journal of Dermatology · 1998
    4. Proanthocyanidins from Grape Seeds Promote Proliferation of Mouse Hair Follicle Cells In Vitro and Convert Hair Cycle In Vivo Acta dermato-venereologica · 1998
    5. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    6. Cutaneous Immunopathology of Androgenetic Alopecia The Journal of the American Osteopathic Association · 1991
    7. Natural Progression of Male Pattern Baldness in Young Men Clinical and Experimental Dermatology · 1991
    8. Quantitative Estimation of Hair Growth: Androgenetic Alopecia in Women and the Effect of Minoxidil Journal of Investigative Dermatology · 1990
    9. Biochemical and Trichological Characterization of Diffuse Alopecia in Women British Journal of Dermatology · 1990
    10. Topical Minoxidil in Early Androgenetic Alopecia Journal of The American Academy of Dermatology · 1987
    11. Androgenetic Alopecia: Treatment Results with Topical Minoxidil Journal of The American Academy of Dermatology · 1987
    12. Use of Topical Minoxidil in the Treatment of Male Pattern Baldness Journal of The American Academy of Dermatology · 1987
    13. The Unit Area Trichogram in the Assessment of Androgen-Dependent Alopecia British Journal of Dermatology · 1983
    14. Hair Diameter in Female Baldness British Journal of Dermatology · 1972