Investigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent
December 2000
in “Phytomedicine”
TLDR Apple-derived procyanidin B-2 can safely promote hair growth in men.
In a study from 2000, 29 male subjects were involved in a double-blind clinical trial to test the effectiveness of procyanidin B-2, a compound from apples, as a hair growth agent. The trial lasted 6 months, with 19 subjects using procyanidin B-2 and 10 using a placebo. The results indicated a significant increase in the number of total hairs and terminal hairs for the procyanidin B-2 group compared to the placebo group, with no adverse side effects reported. The study concluded that procyanidin B-2 is a safe and promising treatment for male pattern baldness.
View this study on sciencedirect.com →
Cited in this study
research Toxicological Studies on Procyanidin B-2 for Extern?al Application as a Hair Growing Agent
Procyanidin B-2 is safe to use on skin as a hair growth product.
research Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo11The authors disclosed conflict of interest.
Procyanidin compounds from grape seeds were found to significantly increase mouse hair growth.
research Acquired scalp alopecia. Part I: A review
Accurate diagnosis is key for treating different kinds of hair loss, and immune response variations may affect the condition and treatment results.
research Proanthocyanidins from Grape Seeds Promote Proliferation of Mouse Hair Follicle Cells In vitro and Convert Hair Cycle In vivo
Grape seed proanthocyanidins can promote hair growth.
research Finasteride in the treatment of men with androgenetic alopecia
Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.
research Cutaneous immunopathology of androgenetic alopecia
research Natural progression of male pattern baldness in young men
Young men with male pattern baldness lose hair density over time without treatment.
research Quantitative Estimation of Hair Growth I. Androgenetic Alopecia in Women: Effect of Minoxidil
Minoxidil promotes hair growth in women with early-stage alopecia.
research Biochemical and trichological characterization of diffuse alopecia in women
Diffuse alopecia in women may be related to androgens and iron deficiency, and basic hormone and nutrient screening is useful.
research Androgenetic alopecia: Treatment results with topical minoxidil
Topical minoxidil is a safe and effective treatment for hair loss caused by androgenetic alopecia.
research Topical minoxidil in early androgenetic alopecia
Using minoxidil on balding scalps can stimulate hair regrowth and increase blood flow. It's an effective treatment for early hair loss.
research Use of Topical Minoxidil in the Treatment of Male Pattern Baldness
Minoxidil effectively regrows hair in male pattern baldness.
research The unit area trichogram in the assessment of androgen-dependent alopecia
The unit area trichogram is a reliable method to assess hair loss and treatment response in people with androgenic alopecia by measuring hair density and thickness.
research HAIR DIAMETER IN FEMALE BALDNESS
Women with thinning hair have thinner hair strands than women without hair loss.