Intrinsic Factors Regulating Hair Growth: Insights Into Growth Factors, Cytokines, Chemokines, and Interferons

    November 2024 in “ Journal of Investigative Dermatology ”
    S.I. Gaumond, N. Maskan, Katherine J. Lee, Peyton V. Warp, Emilee M Dreifus, J.J. Jimenez
    TLDR Red ginseng components help prevent skin aging by reducing inflammation and improving cell function.
    The study investigates the effects of red ginseng-derived components (RGCs) on senescent skin cells, specifically their potential as senolytics. Although RGCs did not exhibit significant senolytic effects, they were found to attenuate senescence markers (p16) and SASP factors (IL-6, IL-8), as well as the inflammatory factor IL-1b. This suggests an improvement in cellular aging and a reduced risk of inflammatory aging spreading to surrounding cells. Additionally, RGCs improved epidermal cell differentiation and collagen synthesis in fibroblasts. Thus, while not senolytic, RGCs demonstrate potent senomorphic properties, making them effective in preventing skin aging through mechanisms distinct from senolysis.
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