Investigation of Intermolecular Interactions in Finasteride Drug Crystals in View of X-ray and Hirshfeld Surface Analysis

    November 2015 in “ Journal of Molecular Structure ”
    Joanna Bojarska, Waldemar Maniukiewicz
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    TLDR Finasteride crystals are held together by hydrogen bonds and weak interactions, forming synthon pseudopolymorphs.
    This study analyzed the intermolecular interactions in finasteride drug crystals using X-ray and Hirshfeld surface analysis. The study found that the crystals are stabilized mainly by hydrogen bonds and weak interactions, and can be classified as synthon pseudopolymorphs. The study can be useful for crystal engineering of aza steroid drugs.
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