Interaction of chronic ethanol exposure and finasteride: sex and strain differences

    Deborah A. Finn, Season L. Long, Michelle A. Tanchuck, John C. Crabbe
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    TLDR Finasteride reduces alcohol withdrawal effects, especially in female mice.
    This study from 2004 investigated the interaction between chronic ethanol exposure and finasteride, a drug used to treat hair loss, in male and female mice. The researchers found that finasteride pretreatment decreased the severity of ethanol withdrawal in mice, with the reduction being more pronounced in female D2 mice. The study also suggested that finasteride may alter ethanol pharmacokinetics, which could explain its effect on withdrawal severity. However, additional studies are needed to determine the mechanism by which finasteride alters chronic ethanol withdrawal severity.
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