Generation of an Integration-Free Human Induced Pluripotent Stem Cell Line MUSIi010-A from Occipital Scalp Fibroblasts of a Male Patient with Androgenetic Alopecia

    July 2019 in “ Stem Cell Research ”
    Nutnicha Tantarungsee, Zaukir Bostan Ali, Rungtip Soi-ampornkul, Chuda Rujitharanawong, Chanika Subchookul, Alisa Ritthaphai, Bootsakorn Boonkaew, Methichit Wattanapanitch, Kanchalit Thanomkitti, Daranporn Triwongwaranat, Chinnavuth Vatanashevanopakorn, Rattapon Thuangtong
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    TLDR Scientists created MUSIi010-A, a stem cell line from a balding man's scalp, to study hair loss and develop potential treatments.
    The paper describes the creation of an integration-free human induced pluripotent stem cell line, MUSIi010-A, from scalp fibroblasts of a male patient with androgenetic alopecia (AGA). The iPSC line was verified to be pluripotent and free of SeV vectors, and can be used for studying pathological mechanisms of AGA. The creation of this cell line also demonstrated the feasibility of generating cells of hair follicles, which could be a novel cell source for developing cell-based treatments for the disease.
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