Immunological Abnormalities in Polycystic Ovary Syndrome

    December 2024 in “ Quality in Sport ”
    Joanna Maria Barcińska, Aleksandra Ostrowska-Czyżewska, Dominika Szwed
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    TLDR PCOS involves immune system issues and inflammation, possibly leading to autoimmune diseases.
    The article reviews the immunological abnormalities in Polycystic Ovary Syndrome (PCOS), which affects 10-15% of women of reproductive age and is a common cause of infertility. PCOS is associated with chronic low-grade inflammation, as evidenced by elevated inflammatory biomarkers (CRP, IL6, TNF alpha) and increased immune cells (Th1 lymphocytes, macrophages). Hormonal imbalances in PCOS may cause immune system dysregulation, leading to autoantibody production linked to autoimmune diseases. The review consolidates current knowledge on these issues and seeks to identify potential therapeutic targets.
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