A Humanized IL-2 Fusion Protein Enhances T Regulatory Cells In Vivo And Restrains Disease In A Murine Model Of Alopecia Areata

    November 2025 in “ The Journal of Immunology ”
    Maddison Lensing, Samuel Connell, Hing C. Wong … Ali Jabbari
    Studysummary In a murine model of alopecia areata, this study observed that the IL-2 fusion protein HCW9302 helped prevent disease development by expanding regulatory T cells and reducing disease-causing effector T cell infiltrates, suggesting potential for using IL-2 fusion proteins in alopecia areata treatment.
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