<i>IGF2BP2</i> and <i>IGFBP3</i> Genotypes, Haplotypes, and Genetic Models Studies in Polycystic Ovary Syndrome

This study examined the association between IGF2BP2 and IGFBP3 gene polymorphisms and polycystic ovary syndrome (PCOS) in 300 southeast Iranian women. It found that the IGF2BP2 rs1470579 and IGFBP3 rs2854744 variants are significantly associated with an increased risk of PCOS, with odds ratios of 3.57 and 2.54, respectively. The research suggests that these genetic variations may influence PCOS development through insulin signaling pathways. Additionally, certain genotype combinations were linked to a reduced risk of PCOS. The study emphasizes the potential of genetic markers in understanding PCOS and highlights the need for further research to explore these genetic associations and their implications for managing PCOS.