Hormonal Interventions in Skin Wounds: A Mini Review
November 2024
in “
Molecular Medicine
”
Studysummary This review highlights that hormones significantly influence the wound healing process by coordinating cellular and molecular activities, and hormonal therapy is emerging as a promising treatment, with current research focusing on optimizing dosages and minimizing side effects. Our plain-language summary of this paper — not a Tressless recommendation.
Hormonal interventions significantly impact skin wound healing by modulating various stages of the process. Recombinant human growth hormone (RHGH) enhances healing by promoting collagen deposition and protein synthesis, beneficial for burns and pressure ulcers without increasing scar formation. Estrogen aids in reducing inflammation and promoting re-epithelialization, especially in postmenopausal women. Androgens support tissue repair but may exacerbate chronic inflammation. Glucocorticoids provide anti-inflammatory effects but can impair skin barrier function with prolonged use. The review underscores the importance of optimizing hormone dosages and delivery methods to maximize therapeutic benefits while minimizing side effects, highlighting the need for personalized treatment plans and further research into hormone interactions and long-term effects.
