Hair Keratinization in Health and Disease
October 1996
in “
Dermatologic clinics
”
keratinization intermediate filaments IF proteins keratins glial fibrillary acidic protein lamin filament assembly coiled-coil central-rod domain N-terminal domain C-terminal domain knob–pocket tetramer assembly coil 1B insert flexible linkers coil 2B residues head domain tail domain low-complexity aromatic-rich segments electrostatic surfaces mutations human diseases keratin GFAP lamin
TLDR Understanding intermediate filaments helps explain hair health and related diseases.
The document discussed the process of hair keratinization in both healthy and diseased states. It highlighted the role of the epidermis and keratinocytes in forming a protective barrier and detailed the molecular bases of several epidermal disorders through genetic and transgenic mouse modeling techniques. The classification of hair disorders, particularly those involving defects in hair fiber formation, was explored using genetic linkage analysis. Recent studies identified the molecular bases of two specific hair disorders, advancing the understanding of hair keratinization at a genetic level.
