Hair growth promoting effects of adipose tissue-derived stem cells

The document from February 2010 presents a study on the effects of adipose tissue-derived stem cells (ADSCs) and their conditioned medium (ADSC-CM) on hair growth. In vitro experiments showed that ADSC-CM significantly increased the proliferation of human dermal papilla cells by up to 130% and activated key signaling pathways for cell growth. The study also found that ADSC-CM promoted the proliferation of keratinocytes and increased hair shaft elongation in human hair follicles. In vivo, the study involved 48 male mice treated with ADSCs or ADSC-CM, which resulted in stimulated hair growth and a 40% increase in hair follicle number, comparable to minoxidil treatment. The research suggests that ADSCs and ADSC-CM can enhance hair growth by increasing cell proliferation and activating the anagen phase of hair cycles, indicating their potential as a treatment for hair loss. The in vitro part of the study used cells from 5 female donors and hair follicles from 5 male volunteers, while the in vivo part used 48 male mice.