Good efficacy achieved by baricitinib in the treatment of anti-MDA5 antibody-positive dermatomyositis with alopecia areata
February 2022
in “Rheumatology”
TLDR Baricitinib was effective in treating a patient with dermatomyositis and hair loss.
The document presents a case study of a 25-year-old female patient with anti-MDA5 antibody-positive dermatomyositis (DM) and alopecia areata. Initial treatment with prednisone, MMF, and tacrolimus for 2 months relieved some symptoms but did not stop hair loss. The addition of baricitinib, a selective JAK1/2 inhibitor, to the treatment regimen resulted in significant relief of the patient's rash, cessation of hair loss, and hair regrowth after 5 months. The document suggests that the overexpression of the JAK-STAT signalling pathway in both DM and alopecia areata may be a key factor in these conditions. This is the first reported case of using baricitinib to treat a patient with anti-MDA5 antibody-positive DM and alopecia areata, with significant results.
View this study on academic.oup.com →
Cited in this study
research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib
A patient with Alopecia Areata had complete hair regrowth after using the drug baricitinib.
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