Gender-Difference in Hair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations

The study used CRISPR-based genome editing to create Fgf5 mutant mice, revealing gender differences in hair length due to dysfunctional FGF5 mutations. Male Fgf5go-malc1 mice exhibited significantly longer hair than females, attributed to frameshift mutations in the Fgf5 gene that disrupted the FGF5 protein and prolonged the anagen phase of hair growth. The research suggested a potential interaction between FGF5 and androgen receptor signaling, influencing hair growth and sexual dimorphism. The findings provided insights into the molecular mechanisms of hair cycle regulation and highlighted the role of FGF5 in hair growth.