Effects of Ganoderma Lucidum Extract and Microneedle Therapy on Hair Growth in C57BL/6N Mice

This study investigated the effects of Ganoderma lucidum extract (GLE) and microneedle therapy system (MTS) on hair growth in C57BL/6N mice. Mice were divided into four groups and treated twice a week for three weeks. Results showed that both GLE + MTS and MTS alone promoted hair growth, with improvements in hair density, thickness, and length compared to the control group. Additionally, the expression of hair growth-related genes and proteins was increased in the GLE + MTS and MTS groups. GLE + MTS was found to be more effective than MTS alone, suggesting that these treatments could be useful for alopecia.