The Use of Minoxidil in the Treatment of Male and Female Androgenetic Alopecia: A Story of More Than 30 Years

    Mauro Barbareschi
    From the encyclopedia
    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

    Studysummary This study discusses that while the precise mechanism of minoxidil is not fully understood, its efficacy in stimulating hair growth and treating androgenetic alopecia is well-supported, with evidence showing it increases hair count and hair follicle size in treated patients.
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    Minoxidil had been used for over 30 years as a hair growth stimulator, although its precise mechanism was not fully understood. It was known to shorten the telogen phase, accelerate the telogen-exogen phase, and induce premature entry of resting hair follicles into the anagen phase, while also increasing hair follicle size. Scientific literature confirmed the efficacy of topically applied minoxidil in humans, with patients showing a significant increase in non-vellus hair count. Minoxidil formulations with low concentrations of propylene glycol were developed for better cosmetic acceptance and dermatological safety. Overall, minoxidil remained a key treatment for androgenetic alopecia.
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