Role of Oxidative Stress in Polycystic Ovary Syndrome

May 2010 in “ Current Women's Health Reviews ”

Joo Yeon Lee, Chin-Kun Baw, Sajal Gupta, Nabil Aziz, Ashok Agarwal

oxidative stress Polycystic Ovary Syndrome PCOS hyperandrogenism ovulatory disturbances insulin resistance obesity malondialdehyde MDA protein carbonyl superoxide dismutase SOD glutathione GSH weight management ovulation insulin sensitivity hormonal profiles hyperandrogenemia

Studysummary This review discusses oxidative stress's role in polycystic ovary syndrome and examines various biomarkers to understand its impact on the disorder's pathogenesis, but reports no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations , October 2008 in “Fertility and Sterility”

This review discusses the definition of polycystic ovary syndrome proposed by the AE-PCOS Society Task Force, emphasizing hyperandrogenism, ovarian dysfunction, and excluding related disorders, while noting potential variations needing more research.

research Genetics of Polycystic Ovary Syndrome: Searching for the Way Out of the Labyrinth

179 citations , July 2005 in “Human Reproduction Update”

This review discusses the genetic basis and familial patterns of polycystic ovary syndrome, noting a strong familial component but inconclusive genetic patterns; it reports no new empirical findings.

research Definitions, Prevalence, and Symptoms of Polycystic Ovaries and Polycystic Ovary Syndrome

278 citations , August 2004 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”

This article reviews the updated ESHRE/ASRM criteria for diagnosing polycystic ovary syndrome, emphasizing the need for continued research and collaboration, but reports no new clinical results.

research Androgen Excess in Women: Experience with Over 1000 Consecutive Patients

947 citations , February 2004 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, polycystic ovary syndrome was the most prevalent cause of androgen excess, and suppressive hormonal therapy improved hirsutism, menstrual dysfunction, and acne in most patients, though side effects were common.

research Prevalence of Polycystic Ovaries in Women with Androgenic Alopecia

84 citations , November 2003 in “European journal of endocrinology”

This study found that women with androgenic alopecia had a higher prevalence of polycystic ovarian morphology and higher androgen levels compared to controls, suggesting a strong association with PCO.

research Androgen Excess Is the Key Element in Polycystic Ovary Syndrome

99 citations , August 2003 in “Fertility and Sterility”

This paper discusses polycystic ovary syndrome with a focus on androgen excess as the primary symptom and notes that insulin resistance may contribute to it in many patients, but provides no new research findings.

research Developmental Origin of Polycystic Ovary Syndrome: A Hypothesis

430 citations , July 2002 in “Journal of Endocrinology”

This hypothesis paper suggests that PCOS may result from genetically determined ovarian hypersecretion of androgens, influencing hormone regulation and insulin resistance, with obesity further affecting its severity; no new clinical results are reported.

research Prevalence of Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study

633 citations , September 1998 in “The Journal of Clinical Endocrinology and Metabolism”

This study observed that among a cohort of reproductive-aged women in the U.S., the prevalence of PCOS was about 4.0%, with no significant racial differences between White and Black women.

research Current Concepts of Polycystic Ovary Syndrome

60 citations , June 1997 in “Baillière's clinical obstetrics and gynaecology”

This article reviews the potential mechanisms underlying polycystic ovary syndrome, emphasizing insulin resistance and hormone dysregulation, and reports no new research findings.

A Prospective Study of the Prevalence of Clear-Cut Endocrine Disorders and Polycystic Ovaries in 350 Patients Presenting with Hirsutism or Androgenic Alopecia

research A Prospective Study of the Prevalence of Clear-Cut Endocrine Disorders and Polycystic Ovaries in 350 Patients Presenting with Hirsutism or Androgenic Alopecia

135 citations , August 1994 in “Clinical Endocrinology”

In this study of women with hirsutism or androgenic alopecia, diverse underlying endocrine disorders including polycystic ovaries and various enzyme deficiencies were detected, often associated with elevated testosterone levels.