Development and Evaluation of a Fish Skin-Derived Acellular Dermal Matrix for Diabetic Wound Healing: In Vitro and In Vivo Assessment

    January 2026 in “ Journal of Biomaterials Applications ”
    Mekha Grace Varghese, Thomas George Valliaveettil, Binsi Puthanpurakkalkizhakkethil Kamalamma, Nibu Varghese, Yogesh Bharat Dalvi, Nebu George Thomas, R. A. Rajeevan, Anoop Chandran, Sukumaran Anil
    Studysummary This study found that a fish skin-derived acellular dermal matrix improved wound healing in diabetic rats, showing faster closure rates and enhanced tissue regeneration compared to commercial alternatives. Our plain-language summary of this paper — not a Tressless recommendation.
    The study developed a fish skin-derived acellular dermal matrix (FSADM) from yellow fin tuna for diabetic wound healing, demonstrating preserved collagen structure and excellent biocompatibility both in vitro with L929 fibroblasts and in vivo in Sprague-Dawley rats. In a diabetic rat model, FSADM-treated wounds closed significantly faster than those treated with commercial alternatives, achieving 100% closure by day 21. Histological analysis showed enhanced epithelialization, hair follicle formation, and angiogenesis in FSADM-treated wounds. The study concludes that FSADM is a promising biomaterial for diabetic wound care, though further clinical validation is needed.
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