Finasteride

    October 2013 in “ Handbook of Metabolic Pathways of Xenobiotics ”
    Jiangbo Du
    TLDR Finasteride is mostly broken down in the body and excreted in urine and feces.
    Finasteride was a 5α-reductase type II inhibitor used for treating benign prostatic hyperplasia and pattern baldness. In studies with healthy human volunteers, after oral administration, 39% of the [14C]-finasteride dose was recovered in urine and 57% in feces, with less than 1% excreted unchanged. The major circulating metabolite was ω-hydroxy finasteride, accounting for 12% of total radioactivity, while finasteride-ω-oic acid was the primary metabolite found in urine, making up 18%. Other metabolites included 6α-OH finasteride and its glucuronide conjugate, as well as the glucuronide conjugate of the acid metabolite.
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      community risks with finasteride and dutasteride

      in Research/Science  139 upvotes 5 months ago
      Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.
      Can I still save my hairline at age of 15?

      community Can I still save my hairline at age of 15?

      in General  478 upvotes 1 month ago
      A 15-year-old is concerned about hair loss, possibly at Norwood 2 or 3, and is using shampoos and conditioners recommended by a trichologist. Suggestions include considering topical minoxidil and consulting a doctor about topical anti-DHT treatments like finasteride or RU58841, but avoiding 5-alpha-reductase inhibitors at this age.

      community Dutasteride power compared to finasteride

      in Finasteride/Dutasteride  15 upvotes 4 months ago
      Dutasteride is generally considered more effective than finasteride for hair regrowth, with some users experiencing better results, especially at higher doses. However, individual responses vary, and some users report side effects or no response to either treatment.

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