Exploring Factors That Influence the Measurement of Patient-Reported Impacts of Alopecia Areata

April 2025 in “ Dermatology and Therapy ”

Arash Mostaghimi, Adam Gibson, Gregory B. Dwyer, Yemi Oluboyede, Iyar Mazar, Kristina G. Gorbatenko-Roth, Ernest H. Law

Alopecia Areata hair regrowth psychosocial outcomes

Studysummary This study suggests that sustained hair regrowth is necessary to significantly change patient-reported psychosocial outcomes in alopecia areata, with time since regrowth being a critical factor in measuring adaptation.

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Patient-Reported Hair Loss and Its Impacts as Measured by the Alopecia Areata Patient Priority Outcomes Instrument in Patients Treated with Ritlecitinib: The Allegro Phase 2b/3 Randomized Clinical Trial

research Patient-Reported Hair Loss and Its Impacts as Measured by the Alopecia Areata Patient Priority Outcomes Instrument in Patients Treated with Ritlecitinib: The Allegro Phase 2b/3 Randomized Clinical Trial

4 citations , October 2024 in “American Journal of Clinical Dermatology”

This study found that ritlecitinib improved patient-reported outcomes related to hair growth in individuals with alopecia areata, with some experiencing clinically meaningful hair regrowth, although changes in emotional symptoms and activity limitations were minimal and similar across treatment groups.

research Alopecia Areata Treatment Patterns and Satisfaction: Results of a Real-World Cross-Sectional Survey in Europe

2 citations , October 2024 in “Dermatology and Therapy”

In this study, dermatologists expressed low satisfaction with traditional treatments for severe alopecia areata, noting that some patients stop treatment due to disease worsening, indicating a need for more effective options.

Physician and Patient-Reported Severity and Quality of Life Impact of Alopecia Areata: Results from a Real-World Survey in Five European Countries

research Physician and Patient-Reported Severity and Quality of Life Impact of Alopecia Areata: Results from a Real-World Survey in Five European Countries

2 citations , October 2023 in “Dermatology and therapy”

This study conducted in Europe found that both physicians and patients generally agreed on the severity of alopecia areata, with higher physician-rated severity linked to increased patient-reported burdens such as anxiety, depression, and work impairment.

research Efficacy and Safety of Ritlecitinib in Adolescents with Alopecia Areata: Results from the ALLEGRO Phase 2b/3 Randomized, Double-Blind, Placebo-Controlled Trial

48 citations , July 2023 in “Pediatric Dermatology”

This study found that among adolescents with alopecia areata and significant hair loss, treatment with ritlecitinib resulted in greater hair regrowth and self-reported improvement compared to placebo over 48 weeks, with common side effects including headache, acne, and nasopharyngitis.

research Efficacy and Safety of Ritlecitinib in Adults and Adolescents With Alopecia Areata: A Randomised, Double-Blind, Multicentre, Phase 2b–3 Trial

227 citations , April 2023 in “The Lancet”

Ritlecitinib effectively treats alopecia areata and is well-tolerated.

research The Association of Alopecia Areata-Related Emotional Symptoms with Work Productivity and Daily Activity Among Patients with Alopecia Areata

29 citations , December 2022 in “Dermatology and Therapy”

This study reported that patients with alopecia areata experienced significant increases in work productivity loss and activity impairment due to worsening emotional symptoms, highlighting a need for better treatments.

The Relationship Between Patient-Reported Severity of Hair Loss and Health-Related Quality of Life and Treatment Patterns Among Patients with Alopecia Areata

research The Relationship Between Patient-Reported Severity of Hair Loss and Health-Related Quality of Life and Treatment Patterns Among Patients with Alopecia Areata

4 citations , March 2022 in “Dermatology and Therapy”

This study found that alopecia areata severity significantly influences the health-related quality of life impacts and treatment patterns among affected individuals.

research Two Phase 3 Trials of Baricitinib for Alopecia Areata

148 citations , March 2022 in “The New England Journal of Medicine”

In two phase 3 trials, this study found that oral baricitinib significantly improved hair regrowth compared to placebo in adults with severe alopecia areata after 36 weeks, though longer trials are needed to ascertain its long-term efficacy and safety.

research Validation of the Alopecia Areata Patient Priority Outcomes Questionnaire in Adults and Adolescents with Alopecia Areata

22 citations , November 2021 in “Dermatology and Therapy”

This study found that the Alopecia Areata Patient Priority Outcomes questionnaire is a reliable and valid tool for measuring the severity and impact of hair loss in individuals with alopecia areata.

research Association of Resilience and Perceived Stress in Patients with Alopecia Areata: A Cross-Sectional Study

2 citations , July 2021 in “Journal of The American Academy of Dermatology”

People with alopecia who are more resilient tend to feel less stressed.

research Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review

67 citations , March 2021 in “Dermatology and Therapy”

This review discusses the substantial impact of alopecia areata on patients' health-related quality of life, highlighting issues such as personality changes, emotional and social difficulties, and a common occurrence of alexithymia, and emphasizes the need for more specific assessment tools.

research A Large Cross-Sectional Survey Study of the Prevalence of Alopecia Areata in the United States

63 citations , March 2020 in “Clinical Cosmetic and Investigational Dermatology”

This study suggests that the prevalence of alopecia areata in the US remains similar to high estimates from the 1970s, with significant implications for quality of life.

research Alopecia Areata: Treatment Options and Efficacy

182 citations , December 2017 in “Journal of the American Academy of Dermatology”

This article reviews current and emerging treatments for alopecia areata, including Janus kinase inhibitors, highlighting variability in clinical outcomes and the lack of sustained remission.

Alopecia Areata: Current Situation and Perspectives