Evidence on Hidradenitis Suppurativa as an Autoinflammatory Skin Disease

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease influenced by genetic factors, immune system dysregulation, and environmental factors like smoking and obesity. The disease involves hyperactivation of the innate immune system, leading to tissue damage and activation of the adaptive immune response, which is crucial in chronic stages. Recent studies highlight the role of autoinflammation in HS, with evidence linking it to monogenic and polygenic autoinflammatory syndromes (AIDs). The review underscores the need for further research to understand HS's pathogenic mechanisms and develop new therapeutic strategies.