Evaluation of Topical Sodium Valproate-Loaded Nano Spanlastics Formulation versus Minoxidil® 5% in The Treatment of Female Pattern Hair Loss Using Transdermal Delivery: A Comparative Study

    Amany Moustafa Abdel-Moiti, Farid Abd-Elreheim Badria, Sara Hamdy Fouad Aly, Hassan Abdel-Raheim Fayed
    TLDR Topical Valproic acid and 5% Minoxidil both significantly increase hair count in Female Pattern Hair Loss, with similar side effects.
    The study evaluated the effectiveness of topical Valproic acid (VPA) and 5% topical minoxidil in treating Female Pattern Hair Loss (FPHL). It included 81 patients with FPHL, divided into three groups: 27 treated with topical sodium valproate-loaded nano spanlastics formulation, 27 treated with minoxidil® 5% lotion, and 27 treated with saline using transdermal delivery for 6 months. The results showed that both VPA and minoxidil significantly increased the total hair count compared to the control group (P = 0.047). Adverse events were moderate and self-limiting in both groups, with comparable prevalence rates (P = 0.72). The study concluded that topical VPA is a potential therapy option for FPHL.
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