Evaluation of Topical Sodium Valproate-Loaded Nano Spanlastics Formulation Versus Minoxidil 5% in the Treatment of Female Pattern Hair Loss Using Transdermal Delivery: A Comparative Study

    January 2023 in “ The Egyptian Journal of Hospital Medicine ”
    Amany Moustafa Abdel-Moiti, Farid Abd-Elreheim Badria, Sara Hamdy Fouad Aly, Hassan Abdel-Raheim Fayed
    Image of study
    TLDR Topical Valproic acid and 5% Minoxidil both significantly increase hair count in Female Pattern Hair Loss, with similar side effects.
    The study evaluated the effectiveness of topical Valproic acid (VPA) and 5% topical minoxidil in treating Female Pattern Hair Loss (FPHL). It included 81 patients with FPHL, divided into three groups: 27 treated with topical sodium valproate-loaded nano spanlastics formulation, 27 treated with minoxidil® 5% lotion, and 27 treated with saline using transdermal delivery for 6 months. The results showed that both VPA and minoxidil significantly increased the total hair count compared to the control group (P = 0.047). Adverse events were moderate and self-limiting in both groups, with comparable prevalence rates (P = 0.72). The study concluded that topical VPA is a potential therapy option for FPHL.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Better Than Minoxidil? Topical Sodium Valproate

      in Research/Science  53 upvotes 2 months ago
      Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

      community New & Improved Hair Growth Stack for Maximum Results

      in Treatment  2 upvotes 3 months ago
      A user shared a hair growth stack using minoxidil sulfate, valproic acid, bimatoprost, blue copper peptide, and other ingredients, emphasizing a gel-based formula for better skin tolerance. Another user suggested adding a 5-alpha-reductase inhibitor like finasteride or dutasteride for more effective long-term results.

      community My results & the importance of nutrition on hair health and growth. (M/30, Diffuse Thinner)

       6 upvotes 5 years ago
      A 30-year-old man with diffuse hair thinning shared his hair regrowth regimen, which includes increasing Vitamin D intake, taking oral castor oil, using a dermapen, and various supplements like Glycine, K2, Vitamin E, Vitamin C, Aspirin, Sodium Bicarbonate, and a multivitamin. He also mentioned inconsistent use of Minoxidil, Peppermint Oil, Zix, and topical Castor Oil, and negative side effects from Finasteride, RU58841, and Nizoral.

      community Topical fin only result - 2 years

      in Progress Pictures  249 upvotes 11 months ago
      A user shared their two-year progress using only topical finasteride for hair loss, recently adding keto shampoo, and plans for a hair transplant. They experienced regrowth and halted hair loss without using minoxidil due to side effects.

    Related Research

    9 / 9 results