Extracellular vesicles (EVs) show potential in skin therapy due to their protein cargo with anti-inflammatory and immunomodulatory properties. This review analyzed 52 proteomic studies from the past 15 years, revealing significant heterogeneity in EV protein content, with 40% of 13,000 proteins appearing in only one study. Factors like EV source and isolation method accounted for only 25-60% of variance in protein cargo. Mesenchymal stem cell-derived EVs were particularly rich in proteins linked to wound healing and skin therapy. The study highlights the need for standardized methods to better understand how process conditions affect EV protein cargo.
February 2024 in “Skin health and disease” Exosomes could improve skin and hair treatments but are limited by cost, production difficulty, and need for more research.
10 citations
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January 2024 in “Journal of Cosmetic Dermatology” Exosomes have potential in skin treatments but need more research and are only used topically in the U.S.
1 citations
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June 2023 in “Journal of Cosmetic Dermatology” Exosome treatment for hair growth is promising but not FDA-approved and needs more research on safety and how it works.
10 citations
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February 2022 in “Journal of cosmetic dermatology” Exosomes from fat-derived stem cells may help regrow hair.
271 citations
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May 2019 in “Cells” The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.
May 2023 in “Cytotherapy” Hair follicle and adipose cell vesicles both protect neurons and reduce inflammation similarly.
7 citations
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December 2022 in “Frontiers in Bioengineering and Biotechnology” Extracellular vesicles show promise for wound healing, but more research is needed to improve their stability and production.
4 citations
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August 2025 in “Frontiers in Immunology” Mesenchymal stem cells and their vesicles may effectively treat skin diseases, but more research is needed.
106 citations
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August 2021 in “Pharmaceuticals” Extracellular vesicles help heal skin wounds and could be used for better treatments.
