Ethnobotany, Phytochemistry, Pharmacology, and Conservation of the Genus Calanthe R. Br. (Orchidaceae)

March 2022 in “ Journal of Ethnopharmacology ”

Consolata Nanjala, Jing Ren, Fredrick Munyao Mutie, Emmanuel Nyongesa Waswa, Elizabeth Syowai Mutinda, Wyclif Ochieng Odago, Moses Mutuse Mutungi, Guang‐Wan Hu

Calanthe secondary metabolites hair restoration

TLDR Calanthe orchids have medicinal potential and contain 265 chemical compounds, but are underexplored.

The genus Calanthe, a type of orchid, has been recognized for its medicinal and scientific research values. It has been used in traditional medicine to treat various health conditions such as body swellings, traumatic injuries, joint pain, abdominal discomfort, and toothaches. Secondary metabolites from Calanthe species have shown potential in hair restoration, cancer treatment, anti-inflammatory and antiarthritic, antidiabetic and hepatoprotective activity, antiplatelet aggregation, and antibacterial and antifungal properties. A total of 265 chemical compounds from different chemical classes have been reported from Calanthe, which may be associated with these biological activities. However, many Calanthe species remain underexplored and poorly understood. The study reviewed research articles related to Calanthe species published between 1982 and 2021.

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research Indole Glycosides from Calanthe Discolor with Proliferative Activity on Human Hair Follicle Dermal Papilla Cells

3 citations , May 2021 in “Chemical & Pharmaceutical Bulletin”

Extracts from the Calanthe discolor plant promote hair follicle growth and increase growth factor levels.

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

research Biology and Genetics of Hair

89 citations , September 2010 in “Annual Review of Genomics and Human Genetics”

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

research The Hair Cycle

375 citations , February 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factors in Response to Testosterone Unlike Scalp Cells

51 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Beard cells, unlike scalp cells, produce growth factors in response to testosterone, which may explain differences in hair growth.