Establishment of dermal sheath cell line from Cashmere goat and characterizing cytokeratin 13 as its novel biomarker

    March 2018 in “Biotechnology Letters
    Bing Zhu, Zhiyong Guo, Muzi Jin, Yujuan Bai, Wenliang Yang, Lihua Hui
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    TLDR Scientists created a new cell line from Cashmere goat hair and found that cytokeratin 13 is a unique marker for certain skin cells.
    In the 2018 study, Zhu et al. established cell lines from Cashmere goat hair follicles and identified cytokeratin 13 (CK13) as a novel biomarker for dermal sheath cells (DSCs). They demonstrated that DSCs expressed CK13, which distinguished them from dermal papilla cells (DPCs) that did not express CK13. The expression of CK13 was stronger in peribulbar DSCs compared to nonbulbar DSCs. The discovery of CK13 as a biomarker for DSCs provides a tool for future research on dermal stem cells and their interactions during the hair cycle, potentially aiding in studies of hair follicle regeneration.
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