Epidermal Stem Cells in Wound Healing and Regeneration

January 2020 in “ Stem Cells International ”

Ronghua Yang, Jingru Wang, Xiaohong Chen, Yan Shi, Julin Xie

epidermal stem cells hair follicles keratinocytes skin development stem cell transplantation endothelial cell transformation vascular formation wound healing regeneration

TLDR Epidermal stem cells help heal skin, but how they work is still unclear.

The document reviewed the role of epidermal stem cells, located in the basal layer of the epidermis and hair follicles, in skin development, metabolism, and injury repair. It highlighted significant advancements in understanding these cells at the cellular and molecular levels. Stem cell transplantation was found to aid in skin healing, endothelial cell transformation, and vascular formation, with local stem cells capable of transforming into keratinocytes and other skin-associated tissues. However, the exact mechanisms by which epidermal stem cells contribute to wound healing and regeneration remained unclear. The review aimed to summarize the biological characteristics of these cells and their clinical applications, while also discussing future research directions.

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