Role of Epidermal Stem Cells in Repair of Partial-Thickness Burn Injury After Using Moist Exposed Burn Ointment (MEBO): Histological and Immunohistochemical Study

January 2014 in “ Tissue and Cell ”

Mohamed Radwan El-Hadidy, A. R. EL-Hadidy ., A. Bhaa, S.A. Asker, Shirene Abo Mazroa

epidermal stem cells Moist Exposed Burn Ointment cytokeratin 19 CK19 skin regeneration burn wound healing MEBO

TLDR MEBO ointment helps activate and grow skin stem cells for burn healing.

This study investigated the effects of Moist Exposed Burn Ointment (MEBO®) on the activation and proliferation of epidermal stem cells in 21 patients with partial-thickness burns. By examining the expression of cytokeratin 19 (CK19), a marker for epidermal stem cells, the study found that MEBO treatment enhanced CK19 immune-reactivity, indicating increased stem cell activity. Over 28 days, gradual skin regeneration was observed, culminating in complete regeneration and a return to basal CK19 levels. The findings suggested that MEBO played a role in promoting epidermal stem cell activation and proliferation during burn wound healing.

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Role of Epidermal Stem Cells in Repair of Partial-Thickness Burn Injury After Using Moist Exposed Burn Ointment (MEBO): Histological and Immunohistochemical Study

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research Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation

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