Elevated Mammalian Target of Rapamycin Gene Expression in Acne Vulgaris Patients

    January 2023 in “ Al-Azhar International Medical Journal /Al-Azhar International Medical Journal ”
    Noha M. Abd El‐Fadeal, Nesma Ibrahim Abdelhay, Nader Ismail, Hesham Nada
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    TLDR Acne patients have higher mTOR gene expression.
    The study investigated the expression of the mTOR gene in acne vulgaris patients compared to healthy controls. It included 50 acne patients and 50 age- and sex-matched healthy individuals. The results showed that mTOR gene expression was significantly higher in acne patients, with a fivefold increase compared to the control group. Although there was a positive but nonsignificant correlation between mTOR expression and the duration of acne, the findings suggest that mTOR could serve as a prognostic biomarker for acne severity and treatment response.
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