Efficacy of Activated Autologous Platelet-Rich Plasma in the Treatment of Diabetic Foot Ulcers: An Evidence-Based Brief Literature Review

This literature review discussed the potential of activated autologous platelet-rich plasma (aaPRP) as an adjuvant therapy for diabetic foot ulcers (DFUs), a complication affecting 6.3% of the global population with high treatment costs and recurrence rates. AaPRP, rich in bioactive proteins like growth factors and cytokines, was noted for its regenerative, antioxidative, anti-inflammatory, and antimicrobial properties, and its autologous nature made it a safe treatment option. The review explored the pathogenesis of DFUs and how aaPRP could address these issues to enhance wound healing, along with a brief overview of its isolation method and current expert opinions. Existing evidence supported the use of aaPRP in improving DFU treatment outcomes.