Efficacy of Oral Tofacitinib in the Treatment of Lichen Planopilaris

    April 2018 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    B. Sallee, Lindsey Bordone, Angela M. Christiano
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    TLDR Oral tofacitinib significantly improves lichen planopilaris symptoms without adverse effects.
    The study investigated the efficacy of oral tofacitinib in treating lichen planopilaris (LPP), a type of lymphocytic scarring alopecia. Eight patients were treated, showing significant improvement in the LPP activity index (LPPAI) by 30-94% (p=0.0014). Some patients required increased dosage for a measurable response. LPP symptoms flared upon withdrawal of tofacitinib but were controlled again upon re-initiation. No adverse effects or significant changes in laboratory values were reported. The findings suggested that JAK inhibitors like tofacitinib could be a promising treatment for LPP, warranting further randomized placebo-controlled trials.
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      community can someone help me identify these pls

      in Treatment 3 months ago
      The user is experiencing diffuse thinning and inflammation despite using 2.5mg dutasteride daily, ciclopirox, and ketoconazole shampoos. They are considering treatments like hydroxychloroquine and JAK inhibitors due to suspected scarring alopecia and have faced challenges in obtaining a scalp biopsy.

      community IGE Hair Loss and Miniaturization

      in Chat  3 upvotes 10 months ago
      A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

      community Topical solution recommendation

      in Treatment  2 upvotes 6 months ago
      The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community Topical solution recommendation

      in Product  1 upvotes 6 months ago
      The user is using finasteride 1mg every other day and seeks a topical solution to complement it, excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

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