Efficacy of Oral Tofacitinib in the Treatment of Lichen Planopilaris

    April 2018 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    B. Sallee, Lindsey Bordone, Angela M. Christiano
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    TLDR Oral tofacitinib significantly improves lichen planopilaris symptoms without adverse effects.
    The study investigated the efficacy of oral tofacitinib in treating lichen planopilaris (LPP), a type of lymphocytic scarring alopecia. Eight patients were treated, showing significant improvement in the LPP activity index (LPPAI) by 30-94% (p=0.0014). Some patients required increased dosage for a measurable response. LPP symptoms flared upon withdrawal of tofacitinib but were controlled again upon re-initiation. No adverse effects or significant changes in laboratory values were reported. The findings suggested that JAK inhibitors like tofacitinib could be a promising treatment for LPP, warranting further randomized placebo-controlled trials.
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