Efficacy of Combined Treatment with Adipose Tissue Stem Cell Exosomes (ASCE) and Microneedling for Facial Skin Aging: A 12-Week Prospective, Randomized, Split-Face Study

    November 2023 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    B.S. Cho
    Image of study
    TLDR Combining stem cell exosomes with microneedling improves facial skin aging effectively and safely.
    This study evaluated the efficacy of combined treatment with adipose tissue stem cell exosomes (ASCE) and microneedling for facial skin aging in 28 individuals over a 12-week period. Participants received ASCE on one side of the face and a saline placebo on the other, followed by microneedling. Results showed significant improvements in skin wrinkles, elasticity, hydration, and pigmentation on the ASCE-treated side compared to the control side, as measured by the Global Aesthetic Improvement Scale (p = 0.005). Histopathological evaluations supported these clinical findings, and no serious adverse events were reported, indicating that ASCE combined with microneedling is an effective and safe treatment for facial skin aging.
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