Efficacy of Combined Treatment with Adipose Tissue Stem Cell Exosomes (ASCE) and Microneedling for Facial Skin Aging: A 12-Week Prospective, Randomized, Split-Face Study

This study evaluated the efficacy of combined treatment with adipose tissue stem cell exosomes (ASCE) and microneedling for facial skin aging in 28 individuals over a 12-week period. Participants received ASCE on one side of the face and a saline placebo on the other, followed by microneedling. Results showed significant improvements in skin wrinkles, elasticity, hydration, and pigmentation on the ASCE-treated side compared to the control side, as measured by the Global Aesthetic Improvement Scale (p = 0.005). Histopathological evaluations supported these clinical findings, and no serious adverse events were reported, indicating that ASCE combined with microneedling is an effective and safe treatment for facial skin aging.