Efficacy of Combined Treatment with Adipose Tissue Stem Cell Exosomes (ASCE) and Microneedling for Facial Skin Aging: A 12-Week Prospective, Randomized, Split-Face Study

    November 2023 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    B.S. Cho
    Image of study
    TLDR Combining stem cell exosomes with microneedling improves facial skin aging effectively and safely.
    This study evaluated the efficacy of combined treatment with adipose tissue stem cell exosomes (ASCE) and microneedling for facial skin aging in 28 individuals over a 12-week period. Participants received ASCE on one side of the face and a saline placebo on the other, followed by microneedling. Results showed significant improvements in skin wrinkles, elasticity, hydration, and pigmentation on the ASCE-treated side compared to the control side, as measured by the Global Aesthetic Improvement Scale (p = 0.005). Histopathological evaluations supported these clinical findings, and no serious adverse events were reported, indicating that ASCE combined with microneedling is an effective and safe treatment for facial skin aging.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 27 results

      community Injecting stomach fat into the scalp could cure baldness in just six months

      in Update  114 upvotes 6 years ago
      A potential treatment for hair loss that involves injecting fat into the scalp; the role of testosterone and estrogen in thinning fat tissue under the skin; research on using lard to treat androgenic alopecia, as well as PRP + ACELL/amniotic stem cell treatments; and ongoing clinical trials by doctors involved in the study.

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 2 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Topical finasteride now the safest possible path?

      in Finasteride/Dutasteride  82 upvotes 5 months ago
      Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

    Similar Research

    5 / 1000+ results