The Clinical Efficacy and Mechanism of Action of Alitretinoin in the Treatment of Alopecia Areata

    January 2026 in “ Annals of Dermatology ”
    Jung-Min Shin, Bogyeong Go, Young-Joon Seo … Moon-Bum Kim
    Studysummary This source suggests that alitretinoin may be a safe and potentially effective treatment for patients with mild to moderate alopecia areata not responding to conventional therapies, though further research is needed to confirm its role, either alone or as an adjunct.
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    Research cited in this study 7

    1. Guidelines for the Management of Patients with Alopecia Areata in Korea: Part II Systemic Treatment Annals of Dermatology · 2023
    2. Alopecia Areata: A Comprehensive Review of Pathogenesis and Management Clinical Reviews in Allergy & Immunology · 2017
    3. Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles Scientific reports · 2017
    4. Treatment of Alopecia Universalis with Oral Alitretinoin: A Case Report JAAD case reports · 2017
    5. Complete Remission of Alopecia Areata Under Treatment of Chronic Hand Eczema with Alitretinoin European Journal of Dermatology · 2013
    6. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    7. Pitx2, A β-Catenin-Regulated Transcription Factor, Regulates The Differentiation Of Outer Root Sheath Cells Cultured In Vitro Journal of dermatological science · 2009